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Summary of results
| Domain | Measure | Tolcapone effect size versus placebo |
Predicted COMT genotype effect |
|---|---|---|---|
| Clinical | CGI | 0.35 (small to medium sized) | Yes |
| Cognitive out of scanner | RBANS | 0.22 (small) | No |
| Behavioral | NPI | 0.25 (small) | Yes |
| Cognitive (in scanner) | N-back | – | – |
CGI, Clinical Global Impressions scale; RBANS, Repeatable Battery for the Assessment of Neuropsychological Status; NPI, Neuropsychiatric Inventory-Questionnaire; COMT, catechol-o-methyltransferase.
