Table 3.

Association between PPFU inclusion and poor neonatal outcomes

	Premature birth (< 37 weeks)
N = 3958	OR	aOR	PSaOR
PPFU	0.77 [0.57—1.02]	0.66[0.49–0.89]**	0.63[0.46–0.86]**
Social deprivation indexa	1.08 [1.01 – 1.16]*	1.16[1.04–1.30]*
Maternal age	1.03 [1.01 – 1.04]***	1.03[1.01–1.05]**
Parity	1.00 [0.93—1.07]	0.91[0.83–0.98]*
Pre-pregnancy body mass index (kg/m2)	1.01 [0.99—1.03]	0.99[0.98–1.01]
Maternal origin
Caucasian	ref	ref
Asian	1.17 [0.84—1.61]	1.18[0.84–1.63]
Sub-Saharan Africa	1.13 [0.91—1.40]	1.15[0.92–1.44]
High medical risk level before pregnancyb	2.46 [1.92—3.12]***	2.44[1.89–3.12]***
High obstetrical risk level before pregnancyc	1.67 [1.35—2.07]***	1.58[1.26–1.98]***
	Premature birth (< 34 weeks)
N = 3958	OR	aOR	PSaOR
PPFU	0.65 [0.43—0.95]*	0.53[0.34–0.79]**	0.52[0.34–0.78]**
Social deprivation indexa	1.18 [1.02—1.36]*	1.28[1.11–1.49]**
Maternal age	1.04 [1.01—1.06]**	1.05[1.02–1.07]***
Parity	1.03 [1.01—1.05]*	0.77[0.68–0.86]***
Pre-pregnancy body mass index (kg/m2)	1.04 [1.02 – 1.06]	1.02[0.99–1.04]
Maternal origin
Caucasian	ref	ref
Asian	1.30 [0.84—1.96]	1.31[0.84–1.98]
Sub-Saharan Africa	1.37 [1.04—1.82]*	1.47[1.10–1.97]**
High medical risk level before pregnancyb	2.26 [1.77 – 2.86]***	2.45[1.77–3.34]***
High obstetrical risk level before pregnancyc	1.83 [1.50 – 2.23]***	1.70[1.27–2.26]***
	Small for gestational aged
N = 3958	OR	aOR	PSaOR
PPFU	1.17 [0.96 – 1.42]	1.06 [0.86 – 1.30]	1.07 [0.86 – 1.33]
Social deprivation indexa	1.09 [1.00 – 1.18]*	1.07 [0.98 – 1.16]
Maternal age	0.99 [0.98 – 1.00]	1.01 [0.99 – 1.02]
Parity	0.87 |0.82 – 0.92]***	0.87 [0.81 – 0.93]***
Pre-pregnancy body mass index (kg/m2)	0.96 [0.95 – 0.97]***	0.96 [0.95 – 0.98]***
Maternal origin
Caucasian	ref	ref
Asian	1.27 [0.99 – 1.63]	1.27 [0.98 – 1.62]
Sub-Saharan Africa	1.36 [1.16 – 1.60]***	1.45 [1.22 – 1.71]***
High medical risk level before pregnancyb	1.14 [0.91 – 1.41]	1.20 [0.96 – 1.50]
High obstetrical risk level before pregnancyc	0.83 [0.70 – 1.00]	0.93 [0.78 – 1.12]

PPFU Personalized pregnancy follow-up

OR Odd ratio

aOR Adjusted OR, adjustment on maternal age, parity, SDI, BMI, high medical risk level before pregnancy and high obstetrical risk level before pregnancy

PSaOR Propensity score adjusted OR, patients in the PPFU group were matched to two patients in the standard care group based on maternal age, parity, BMI, high medical risk level before pregnancy and high obstetrical risk level before pregnancy

^*p < 0.05

^**p < 0.01

^***p < 0.001

^asimple sum of 4 deprivation dimensions: social isolation, poor or insecure housing condition, not work-related household income, and no permanent heath care insurance

^bdefined as the presence of one or more of: history of cardiac disease, hypertension, diabetes, venous thrombosis, pulmonary embolism, Graves’ disease, asthma, homozygous sickle cell anemia, thrombocytopenia, coagulation disorder, a rare or systemic disease, nephropathy, HIV infection, psychiatric disease

^cdefined by a history of one or more of the following: pre-eclampsia, fetal growth restriction, preterm delivery, fetal or neonatal death

^dSmall for gestational was defined by a birthweight < to the 10th percentile according to the WHO fetal growth charts