Table 1.
GWAS sources for lung cancer and metabolic biomarkers in Europeans and East Asians
| Europeans | East Asians | |||||||
|---|---|---|---|---|---|---|---|---|
| PMID | Sample size | Case number | Web source | PMID | Sample size | Case number | Web source | |
| Exposures | ||||||||
| HDL | 34887591 | 1,320,016 | – | Global Lipids Genetics Consortium (http://csg.sph.umich.edu/willer/public/glgc-lipids2021/) | 36333282 | 125,872 | – |
Korea Biobank Array Project (https://www.koreanchip.org/kba130k) |
| LDL | ||||||||
| TC | ||||||||
| Triglyceride | ||||||||
| FPG | 33402679 | 151,188 | – | MAGIC (https://magicinvestigators.org/downloads/) | ||||
| HbA1c | 28898252 | 123,655 | ||||||
| Smokinga | 30643258 | 518,633 | – | GWAS-Catalog: GCST007327 | NA | NA | NA | NA |
| Alcohol drinkingb | 30643258 | 414,343 | GWAS-Catalog: GCST007328 | NA | NA | NA | NA | |
| Body mass index | 30124842 | 381,275 | IEU OpenGWAS project: ieu-b-40 (https://gwas.mrcieu.ac.uk/datasets/ieu-b-40/) | NA | NA | NA | NA | |
| Outcomes | ||||||||
| Lung cancer | 28604730 | 85,716 | 29,266 | GWAS-Catalog: GCST004748 | 34594039 | 178,726 | 4444 | BioBank Japan PheWeb (https://pheweb.jp/pheno/LuC) |
| LUAD | 66,756 | 11,273 | GWAS-Catalog: GCST004744 | NA | NA | NA | NA | |
| LUSC | 63,053 | 7426 | GWAS-Catalog: GCST004750 | NA | NA | NA | NA | |
| SCLC | 24,108 | 2664 | GWAS-Catalog: GCST004746 | NA | NA | NA | NA | |
FPG fasting plasma glucose, HbA1c glycosylated hemoglobin, HDL high-density lipoprotein cholesterol, LDL low-density lipoprotein cholesterol, TC total cholesterol, SCLC small cell lung carcinoma, LUAD lung adenocarcinoma, LUSC lung squamous cell carcinoma, NA not available
asmoking status (ever vs. never smokers)
bAlcohol consumption (drinks per week)