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. 2023 Apr 26;21:135. doi: 10.1186/s12951-023-01894-3

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Differential expression of miRNAs in HMEXO and AMEXO. (A) Heat map showing differential expression of top 20 miRNAs between AMEXO and HMEXO. (B) Comparison of the differential relative expression of miRNAs between ANEXO and HMEXO by volcano plot. miR-19b-3p (black dot) was considered one of the significantly up-regulated miRNAs in HMEXO. (C) qRT-PCR analysis of miR-133a-3p, miR-19b-3p and miR-30c-5p expression in HMEXO or AMEXO derived from fresh and 3rd passage ADMSCs (n = 3 biological replicates). (D) qRT-PCR analysis of miR-19b-3p expression in abdominal aortic tissue of healthy donor or AAA patients (n = 3 biological replicates). Data are expressed as median (IQR). C, Two-way ANOVA followed by Tukey’s multiple comparison test. D, Two-tailed Mann-Whitney U test