Fig. 10. Chemical structures of Erm methyltransferase inhibitors. Erm inhibitors identified using (A) high throughput screening (HTS), (B) NMR based screening followed by an extensive SAR campaign, (C) in silico docking on ErmC′ and in vitro assays using COMT, (D) virtual screening using ErmC′ 3D structure, and (E) virtual screening then SAR of the lead compound after in vitro studies.
