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. 2023 Feb 19;10(12):2207499. doi: 10.1002/advs.202207499

Figure 3.

Figure 3

Deletion of Tipe2 in NK cells improves the tumor antigen‐specific CD8+ T cell response. A) MC38‐OVA tumor growth in Tipe2 ΔNK/ΔNK; OT1 mice or control OT1 mice. B) Percentages of IFN‐γ‐ or TNF‐α‐producing cells among tumor‐infiltrating OT1 cells upon PMA and Ionomycin stimulation ex vivo 23 days post‐tumor challenge from (A). C) Scheme of splenic CD62L+CD44− naïve OT1 cell transfer into Tipe2 ΔNK/ΔNK or Tipe2 WT/WT mice challenged with MC38‐OVA tumor cells. D) Percentages of IFN‐γ‐ or TNF‐α‐producing cells among tumor‐infiltrating donor‐derived OT1 cells upon PMA and Ionomycin stimulation ex vivo 23 days post‐tumor challenge from (C). A,B,D) Data are mean values ± SEM representative of two independent experiments (n = 6). *p < 0.05, **p < 0.005, ***p < 0.001 (two‐way ANOVA for (A), two‐tailed Student's t‐test for (B) and (D)).