Table 5.

The hazard ratios (HR), C-index, continuous net reclassification index (cNRI) and the integrated discrimination index (IDI) of classification probability scores from MACE and HF network signatures, adjusting for clinical variables and medication use at hospital discharge.

	Hazard Ratio HR (95% CI)	Harrel's C-index (95% CI)	cNRI#	p-value	IDI#	p-value
Major adverse cardiovascular events (MACE)
CDCS
Unadjusted Model A†	1.09 (1.06–1.12)	0.60 (0.56–0.64)	–		–
Adjusted Model B‡	1.10 (1.07–1.13)	0.50 (0.46–0.54)	0.013	0.37	0.002	0.10
Adjusted Model C§	1.07 (1.04–1.10)	0.49 (0.46–0.53)	0.098	0.01	0.017	<0.01
IMMACULATE
Unadjusted Model A†	1.11 (1.03–1.20)	0.63 (0.54–0.71)	–		–
Adjusted Model B‡	1.12 (1.03–1.21)	0.62 (0.53–0.70)	0.021	0.43	0.004	0.27
Adjusted Model C§§	1.13 (1.04–1.22)	0.66 (0.57–0.74)	0.234	0.08	0.017	0.03
Incident heart failure (HF)
CDCS
Unadjusted Model A†	1.19 (1.14–1.24)	0.74 (0.69–0.79)	–		–
Adjusted Model B‡	1.15 (1.10–1.21)	0.43 (0.37–0.48)	0.131	0.13	0.028	0.05
Adjusted Model C§	1.12 (1.06–1.18)	0.55 (0.49–0.60)	0.22	0.02	0.043	<0.01
IMMACULATE
Unadjusted Model A†	1.12 (1.03–1.22)	0.70 (0.62–0.77)	–		–
Adjusted Model B‡	1.12 (1.02–1.22)	0.69 (0.59–0.78)	0.073	0.50	0.006	0.23
Adjusted Model C§§	1.11 (1.01–1.22)	0.73 (0.63–0.81)	0.394	0.06	0.115	<0.01

^† Model is not adjusted for any other factors.

^‡ Model is adjusted for age, gender and BMI. For IMMACULATE, gender is omitted since all patients are male.

^§ Model is further adjusted for ST elevation status at admission, medical history of hypertension and use of beta-blockers, ACE inhibitor, aspirin, clopidogrel, calcium channel antagonist, long-acting nitrate, diuretics, statin and warfarin at hospital discharge.

^§§ Model is further adjusted for ST elevation status at admission, medical history of hypertension and use of beta-blockers, ACE inhibitor and antagonist receptor blocker at hospital discharge.

^# cNRI and IDI are calculated based on 2-year survival and the unadjusted model A is used as the base model.