Figure 6.

Acetalated dextran (Ace-DEX) formulations of AR-12 for Salmonella. (A) Ace-DEX microparticles (MPs) fabricated using an emulsion technique. Scale bar is 1μm.³⁶ (B) Intracellular concentration of AR-12 increases dramatically when delivered via Ace-DEX MPs. (C) AR-12 cytotoxicity is significantly reduced upon encapsulation in Ace-DEX MPs. *** P, 0.001 (D) Epifluorescence micrographs of human monocyte derived macrophages infected with S. Typhi and treated with AR-12 MPs. (E) Intracellular bacterial load is significantly reduced with increasing AR-12 MPs concentration. ** P<0.01, *** P< 0.001.³⁵