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. Author manuscript; available in PMC: 2023 Apr 26.
Published in final edited form as: Transl Res. 2020 Mar 16;220:98–113. doi: 10.1016/j.trsl.2020.03.009

Figure 7.

Figure 7.

Acetalated dextran (Ace-DEX) formulation of HDTs for F. tularensis. (A) Co-treatment of AR-12 and Ace-DEX nanoparticles (NPs) (delivered intranasally) with gentamicin (Gent) (delivered intraperitoneally) doubles survival of mice infected with F. tularensis compared to gentamicin treatment alone. * P <0.05, **P<0.01 compared to control and blank. ^ P <0.05, ^^P<0.01 compared to AR-12. Gent = daily 0.5mg gentamicin/kg. (B) Significant reduction in bacterial load is observed with co-treatment of AR-12 encapsulated in Ace-DEX NPs (AR-12/NP) and gentamicin by Day 6 post infection in both lung and spleen tissues.34 ** P<0.01 compared to blank MP group.