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. 2023 Apr 20;64(4):23. doi: 10.1167/iovs.64.4.23

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Figure 5. — AURKB upregulated the TERT transcription by modulating the phosphorylation and methylation of histone H3. (A) IHC staining and (B) quantitation of H3S10ph and AURKB were performed in UM and paracancerous choroidal tissues. (C) GEPIA analysis revealed a positive correlation between AURKB and TERT expression. (D) Kaplan–Meier survival analysis based on GEPIA suggested TERT was negatively correlated with the overall survival rate for patients with UM. (E) Immunoblotting analysis of H3S10ph and TERT in 92.1 and OMM2.3 cells treated with increasing concentrations of hesperadin. (F, G) ChIP assays were conducted on both DMSO- and hesperadin-treated UM cells to detect the change of H3S10ph and H3K9me2/3. (H) Relative telomere length was detected using dual-labeled fluorescence probe-based RT-qPCR. The significant difference between the treated and the control was tested by the Student t-test using GraphPad Software 8.0.1.