Table 1.
Patient characteristics of the dx cohort (n = 50).
| Patient no. | Patient age [months] | Treatment protocol | sex | Time to event (last follow-up) [months] | % blasts | EGR3 ΔCT Mean | IGHM ΔCT Mean | CD79A ΔCT Mean | BLK ΔCT Mean | PTPN6 ΔCT Mean | HOXA9ΔCT Mean |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 5.0 | Interfant-06 | F | (40.1) | 49 | 8.1850 | 3.9578 | 2.6439 | 5.1517 | 3.8854 | 13.3592 |
| 2 | 6.0 | / | F | / | 82 | 11.2758 | 4.1454 | 2.2853 | 4.3700 | 2.1229 | 3.9204 |
| 3 | 2.0 | Interfant-06 | F | (23.6) | 46 | 9.3618 | 4.8963 | 2.7340 | 4.4007 | 4.4306 | 12.9546 |
| 4 | 6.0 | Interfant-06 | M | (17.1) | 90 | 11.1637 | 9.1284 | 7.8716 | 9.8465 | 10.1343 | 11.5783 |
| 5 | 10.0 | / | M | / | 90 | 8.8214 | 5.4178 | 6.2042 | 10.2556 | 9.6764 | 3.5974 |
| 6 | 2.0 | Interfant-06 | M | (83.6) | 95 | 11.5618 | 6.2522 | 6.9626 | 8.1896 | 8.8812 | 4.9698 |
| 7 | 3.0 | Interfant-06 | F | (5.6) | 96 | 8.5196 | 5.8631 | 2.8374 | −1.4396 | 2.4810 | 11.0093 |
| 8 | 3.0 | Interfant-06 | F | (1.2) | 71 | 8.2271 | 4.9521 | 5.1072 | −0.4361 | 4.2495 | 4.9163 |
| 9 | 3.0 | Interfant-06 | M | (2.5) | 85 | 8.0114 | 4.5490 | 3.3648 | −0.8208 | 2.8412 | 4.5976 |
| 10 | 6.0 | Interfant-06 | F | 9.5 (10.7) | 98 | 12.3136 | 8.2192 | 8.1777 | 8.7455 | 8.1889 | 5.0818 |
| 11 | 0.1 | / | F | / | 96 | 11.2989 | 11.8824 | 9.8611 | 10.2911 | 9.2719 | 8.6964 |
| 12 | 1.0 | / | M | / | 98 | 11.6236 | 11.8944 | 8.6850 | 9.7199 | 9.8527 | 12.3443 |
| 13 | 12.0 | / | F | / | 90 | 9.1826 | 4.9885 | 1.9742 | 3.1891 | −0.3517 | 2.2824 |
| 14 | 4.0 | / | F | / | n/a | 11.4695 | 6.3329 | 3.2521 | 4.4310 | 1.3435 | 11.4825 |
| 15 | 2.0 | Interfant-06 | M | 6.0 (6.0) | 90 | 13.3440 | 4.6279 | 2.6102 | 4.9218 | 1.1705 | 4.6973 |
| 16 | 5.5 | Interfant-06 | M | 9.5 (15.0) | 94 | 9.5330 | 9.9035 | 5.8136 | 6.3955 | 4.2272 | 6.2129 |
| 17 | 1.5 | Interfant-06 | F | 10.0 (13.0) | 92 | 6.2132 | 11.4431 | 8.3688 | 8.4548 | 6.1221 | 6.0703 |
| 18 | 3.0 | Interfant-06 | F | 6.0 (11.5) | 87 | 9.4723 | 9.2393 | 7.5200 | 8.7426 | 4.7647 | 2.0906 |
| 19 | 2.0 | Interfant-06 | F | 10.5 (19) | 96 | 7.2056 | 2.4819 | 2.0453 | −1.9534 | 2.4821 | 7.8537 |
| 20 | 1.5 | Interfant-06 | M | 26.5 (41.0) | 96 | 11.2026 | 5.8739 | 4.8320 | 0.2568 | 6.2901 | 4.4627 |
| 21 | 6.5 | Interfant-06 | M | 24.0 (32.8) | 43 | 8.7817 | 6.5124 | 3.1900 | 0.3659 | 3.1614 | 11.2673 |
| 22 | 6.0 | Interfant-06 | F | 19.5 (23.5) | 94 | 10.0553 | 6.4983 | 2.9073 | −1.3699 | 3.5784 | 11.5891 |
| 23 | 12.0 | Interfant-06 | F | 32.0 (60.6) | 92 | 8.0600 | 6.9642 | 4.0856 | 3.3604 | 1.6443 | 11.1226 |
| 24 | 9.0 | Interfant-06 | M | (84.9) | 93 | 7.0569 | 3.3029 | 1.1508 | 2.1274 | 1.1842 | 8.7665 |
| 25 | 2.0 | Interfant-06 | F | (118.8) | 93 | 10.2925 | 4.4468 | 1.7712 | 2.0883 | 0.4488 | 4.6017 |
| 26 | 3.0 | Interfant-06 | M | 8.0 (108.5) | 96 | 8.7375 | 7.0230 | 3.4687 | 4.0864 | 2.6431 | 13.0872 |
| 27 | 5.5 | Interfant-06 | M | (9.0) | 95 | 9.1105 | 5.8320 | 2.9365 | 4.0461 | 1.5317 | 5.9626 |
| 28 | 5.0 | Interfant-06 | M | 17.0 (33.0) | 97 | 5.0456 | 5.0784 | 2.0327 | 4.8259 | 1.2226 | 5.9922 |
| 29 | 2.0 | Interfant-06 | F | 56.0 (58.6) | 90 | 9.3271 | 3.7605 | 3.9045 | 2.4719 | 4.2582 | 5.3297 |
| 30 | 1.5 | Interfant-06 | F | (146.1) | 88 | 9.8910 | 3.3500 | 2.1610 | 0.6500 | 2.7175 | 5.8358 |
| 31 | 8.3 | Interfant-06 | F | (109.3) | 81 | 6.5075 | 1.0567 | 0.0773 | −0.7910 | 1.6433 | 2.2195 |
| 32 | 8.2 | Interfant-06 | M | (95.9) | 92 | 7.2074 | 1.7896 | 2.8559 | 0.3826 | 0.8519 | 1.7726 |
| 33 | 10.7 | Interfant-06 | M | 8.8 (8.8) | 85 | 2.4138 | -2.0719 | 0.3777 | −0.1263 | 1.5011 | 2.6953 |
| 34 | 1.7 | Interfant-06 | F | (91.5) | 93 | 6.2540 | 1.4646 | 1.9100 | 1.0432 | 2.1243 | 3.8579 |
| 35 | 11.7 | Interfant-06 | F | (73.2) | 95 | 10.9273 | 4.7296 | 1.2813 | 3.3225 | 2.8393 | 2.9311 |
| 36 | 10.4 | Interfant-06 | F | (75.9) | 92 | 10.4144 | 4.0039 | 2.3851 | 3.3520 | 2.9626 | 5.7541 |
| 37 | 2.4 | Interfant-06 | F | (73.8) | 95 | 9.8438 | 5.2626 | 2.1926 | 4.1514 | 3.4033 | 13.3331 |
| 38 | 4.5 | Interfant-06 | M | 16.1 (63.5) | 87 | 11.4891 | 4.6039 | 1.4411 | 3.5708 | 2.5554 | 4.6562 |
| 39 | 1.1 | Interfant-06 | F | 3.3 (15.7) | 93 | 11.9464 | 6.0799 | 2.8532 | 4.2890 | 4.2377 | 12.9071 |
| 40 | 5.3 | Interfant-06 | M | (58.7) | 94 | 10.3705 | 4.6305 | 2.2531 | 3.8496 | 3.0655 | 5.4284 |
| 41 | 6.9 | Interfant-06 | F | (63.2) | 16 | 9.7053 | 5.4245 | 1.3355 | 3.4142 | 5.0462 | 9.2472 |
| 42 | 5.3 | Interfant-06 | M | (60.7) | 88 | 9.5640 | 3.2046 | −0.1283 | 2.8862 | 1.5220 | 3.4737 |
| 43 | 0.6 | Interfant-06 | F | 5.0 (11.9) | 97 | 8.6364 | 5.2214 | 1.5813 | 3.6253 | 2.8227 | 7.9122 |
| 44 | 1.5 | Interfant-06 | M | 17.3 (18.3) | 98 | 9.5745 | 6.0122 | 0.6954 | 3.0358 | 3.6119 | 8.1333 |
| 45 | 4.4 | Interfant-06 | M | 6.6 (10.8) | 82 | 10.2528 | 4.5355 | 0.2110 | 3.4874 | 2.4696 | 4.2993 |
| 46 | 9.1 | Interfant-06 | F | 39.7 (45.2) | 71 | 9.3985 | 5.1434 | 1.5751 | 4.8219 | 2.9164 | 3.1663 |
| 47 | 0.5 | Interfant-06 | F | 8.7 (13.3) | 93 | 9.9358 | 10.9029 | 7.9047 | 7.4532 | 8.7790 | 6.2701 |
| 48 | 6.1 | AIEOP-BFM ALL 2017 | F | 6.6 | n/a | 9.4741 | 11.2982 | 8.5621 | 6.0722 | 10.3424 | 12.6734 |
| 49 | 6.1 | AIEOP-BFM ALL 2017 | F | 8.3 | n/a | 10.5529 | 11.9934 | 8.9069 | 9.1727 | 8.9088 | 4.5847 |
| 50 | 10.6 | / | M | / | n/a | 5.1199 | 10.1187 | 9.3696 | 7.7286 | 11.0893 | 5.0774 |
Samples were taken from PB at the day of diagnosis. Gene expression values are indicated as the ΔCT mean of technical triplicates.
% blasts Blast percentages measured at diagnosis in PB, F female, M male.