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. 2023 Apr 26;14:2401. doi: 10.1038/s41467-023-37532-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a cryoEM map of PN45545 TCR-CD3 complex with MAGEA4 pMHC. b fit of MAGEA4 peptide into the map of the PN45545 complex. c, top-down view of MAGEA4 pMHC with α (orange) and β (purple) CDRs of PN45545 shown as loops. TCR interdomain vector and MHC groove vector are depicted as thin lines. The TCR docking angle reported by TCR3d database is shown. d cryoEM map of PN45428 TCR-CD3 complex with MAGEA4 pMHC. e fit of MAGEA4 peptide into the map (semitransparent surface) of the PN45428 complex. f top-down view of MAGEA4 pMHC with α (orange) and β (purple) CDRs of PN45428 shown as loops. TCR interdomain vector and MHC groove vector are depicted as thin lines. The TCR docking angle reported by TCR3d database is shown. g TCR-based structural alignment of PN45545 (magenta) and PN45428 (green) complexes with MAGEA4 pMHC.