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. 2022 Dec 26;14(4):e00560. doi: 10.14309/ctg.0000000000000560

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© 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 2. — Effects of ABX464 on peripheral blood mononuclear cells (PBMCs). Cells were treated for 6 days with 5 μM ABX464. (a) Cytokine concentrations in the supernatant of PBMCs. (b) Th1/Th17 cells (CD196/CD183 expression) among viable CD4+ cells. (c) Intracellular IFNγ and IL17a expression among viable CD4+ cells. (d) Correlation between miR-124 modulation and Th17-cell inhibition in PBMCs related to ABX464 concentration. Cells were treated for 6 days with different concentrations of ABX464 (not above 10 μM to avoid a cytotoxic effect). Th17-cell inhibition and fold changes in miR-124 were determined in comparison with DMSO-treated cells as a negative control. Mean ± SD are reported. Results were obtained on PBMC isolated from 15 or 16 healthy blood donors and 5 different experiments (panel a), from 11 donors and 3 experiments (panel b), and from 16 donors and 5 experiments (panel c). Dots represent blood samples from different, and mean ± SEM are reported. Dunnett or Dunn test (ns = P > 0.05, *P < 0.05, ***P < 0.001, ****P < 0.0001).