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MiR-124 modulation in rectal tissue (a–c) and blood (d–f) in patients with UC. The number of miR-124 copies was assessed by droplet digital PCR at baseline (a, d) and week 8 (b, e), and fold increase at week 8 compared with baseline (c, f). A total of 576 rectal biopsies from 139 patients and 1,104 blood samples from 229 patients who received ABX464 (25, 50, or 100 mg) or placebo were analyzed. Kruskal-Wallis test (***P < 0.001 vs placebo; ****P < 0.0001 vs placebo).
