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. 2022 Dec 26;14(4):e00560. doi: 10.14309/ctg.0000000000000560

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© 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

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Figure 7. — Effects of ABX464 on cytokine secretion by colons of dextran sodium sulfate (DSS)-induced mice. The colons of untreated healthy mice (H₂O group) or DSS-induced colitis mice treated by ABX464 (DSS + ABX464) or untreated (DSS) were cultured ex vivo at the end of an acute DSS experiment and assessed for cytokine secretions with (a) LegendPlex mu inflammation panel or (b) a LegendPlex mu HSC panel or (c) ELISA. Dots represent colons, and mean ± SEM are reported. The statistics are based on the fold change compared with DSS. Kruskal-Wallis with the Dunn multiple comparison test (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). N = 26 mice per group.