Figure 8.
Effects of ABX464 on CD4+ subsets in the mesenteric lymph nodes (MLNs) of dextran sodium sulfate (DSS)-induced mice. Cells in the MLNs of untreated healthy mice (H2O group), untreated mice with DSS-induced colitis (DSS group), or treated mice with DSS-induced colitis (DSS + ABX464) were collected and stained to determine proportions of (a) interleukin (IL) 17 secretors, (b) interferon (IFN) γ secretors, and (c) Treg cells. Dots represent samples from individual mice, and mean ± SEM are reported. Kruskal-Wallis tests with the Dunn multiple comparison test (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).