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. 2023 Apr 26;9(17):eadi2011. doi: 10.1126/sciadv.adi2011

Fig. 3. The non-canonical inflammasome.

Fig. 3.

(A) CTB binds to GM1 plasma membrane gangliosaccharides to deliver either CTA (left) or LPS serotype O111:B4 (right) into the cytoplasm. CTB binds to the hyperdivergent O-specific polysaccharide chain of LPS serotype O111:B4. (B) LPS serotype O-A (includes O111:B4) binds to CTB to access the cytosol. In contrast, LPS serotype O-B does not bind to CTB and therefore cannot gain access. Both serotypes, however, can be introduced by transfection. (C) Caspase-1 or caspase-11 cleaves GSDMD, releasing an N-terminal p30 fragment that oligomerizes into an approximately 20-nm pore. GSDMD pores collapse the electrochemical gradient and release DAMPs, including IL-1β and IL-18, into the extracellular milieu.