Fig. 5. A network of plasma proteins with a directionally concordant CMR effect (index, orange circles) and their nearest druggable protein (green square with record CVD indication or side effect).

Directly interacting proteins are presented as a thick blue arrow; the remaining druggable proteins were separated by a single intermediate protein. In the presence of ties, all druggable proteins with the same distance are presented. Druggable proteins with a CVD indication or side effect (based on BNF and ChEMBL) are presented as squares. In addition, nonindexing proteins with available plasma pQTL data are represented by an orange outline. Nomenclature: Proteins are referred to by their UniProt entry name to differentiate them from the encoding genes.