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. 2023 Apr 12;616(7958):814–821. doi: 10.1038/s41586-023-05922-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — GO enrichment analysis of genes with increased Pol-II speed across species: C. elegans (21 d vs 1 d), D. melanogaster (heads: 50 d vs 30 d), M. musculus (kidney: 24 mo vs 3 mo), R. norvegicus (liver: 24 mo vs 6 mo), H. sapiens (IMR90: Senescent vs Proliferating). GO enrichment of (a), top 200 (b), top 300 genes with an increase in Pol-II speed change for each species (common terms between the two sets in bold). Color scale indicates the significance of the enrichment (all GO terms enriched with p-values below 0.05, with at least 10 significant genes for each GO categories, Fisher elim test). In all panels, the silhouettes of the organs were created using BioRender (https://biorender.com), and the silhouettes of species are from PhyloPic (https://phylopic.org).