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. 2023 Apr 12;616(7958):814–821. doi: 10.1038/s41586-023-05922-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — GO enrichment for consistently down-regulated (top) or up-regulated (bottom) genes across species during aging (left) or ‘aging intervention’ (right) (aging up-regulated: 92 genes; aging down-regulated: 71 genes; ‘aging intervention’ up-regulated: 164 genes; ‘aging intervention’ down-regulated: 473 genes; as background for the enrichment analysis a set of 4784 orthologue genes between H. sapiens, R. norvegicus, M. musculus, D. melanogaster, C. elegans was used. All p-values *P < 0.05, significant genes > 10, fisher elim test). GO terms related to transcription and splicing are indicated in bold.