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. 2023 Apr 12;616(7958):814–821. doi: 10.1038/s41586-023-05922-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — (a) Western blot experiments confirm the overexpression of the H3-GFP and H4-GFP proteins. (b) Visual confirmation of the Dox induction of H3/H4 expression and FACS sorting of GFP-positive cells. Both the blots and FACS data shown are representative of data obtained from independent experiments produced using the two different IMR90 isolates. (c) Typical immunofluorescence images of H3-GFP, H4-GFP and control IMR90 cells (left) show increased DAPI levels in histone overexpression nuclei. Violin plots (right) quantify this reduction (two-tailed t-test). N specifies the number of cells analyzed per condition.