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. 2023 Apr 12;616(7958):814–821. doi: 10.1038/s41586-023-05922-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — (a) Scatterplots of intronic slope (−log10) for each condition and species (C. elegans, D. melanogaster, M.musculus, R. norvegicus, H. sapiens). (b) Variation of intronic slope (−log10) changes for different introns of the same gene. Distribution of variances of Pol-II speed estimates (slope per intron) for introns within the same gene. Average variance of speed estimates across all introns (i.e. between genes; global average) is shown as a dashed vertical line for C. elegans (21 d vs 1 d; 14 daf-2 d vs 14 d), D. melanogaster (heads 50 d vs 30 d; 50 d vs 10 d), M. musculus (kidney: 24 mo vs 3 mo; 3 DR mo vs 3 mo), R. norvegicus (liver: 24 mo vs 6 mo), H. sapiens (Umbilical vein endothelial (HUVECs); fibroblast fetal lung (IMR90): Senescent vs Proliferating). The vast majority of intra-gene variances are below the average inter-gene variance, suggesting that introns of the same gene have coupled Pol-II elongation speeds. In all panels, the silhouettes of species are from PhyloPic (https://phylopic.org).