Extended Data Fig. 6. Multi-sample patient phylogeny and heterogeneity.
(a) Examples of phylogenetic trees generated by PhylogicNDT (BuildTree module) for selected patients with two samples of the same tumor. Numbers on branches represent the number of SNVs or indels that are added along each branch. Pie graphs below represent cancer cell populations of each subclone, constrained by the pigeonhole principle, estimated by PhylogicNDT (BuildTree module). (b) Scatter plot of MATH scores from patients with multiple tumor samples. Each axis represents the MATH score from one of the samples. (N = 28 patients with multiple samples).