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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: Adv Drug Deliv Rev. 2023 Mar 6;196:114771. doi: 10.1016/j.addr.2023.114771

Figure 4:

Figure 4:

Proposed model of the role of SNF5 in regulating immune escape upon mechanical stimulation in melanoma. The upregulated expression of SNF5 on the stiffer matrix activates the expression of immune escape genes by activating the phosphorylation of STAT3, thereby inhibiting T cells recognition and infiltration. Illustration adapted with permission from Chen et al. 113.