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. 2023 Apr 26;13:6821. doi: 10.1038/s41598-023-32293-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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AI semisupervised learning was more effective than non-AI tools for trajectory analysis of cardiomyocyte scRNAseq data from pig hearts (A) Seurat-Monocle pipeline UMAP plot visualizing 12 cardiomyocyte clusters (CMs1-CMs12), where these clusters were identified by Seurat pipeline³⁰. (B) The proportion of cardiomyocytes from each cluster CMs1-CMs12 is displayed for each injury group and time point. (C) Summary of clusters resulting from the Seurat-Monocle pipeline that are: exclusive for ARp1-P28, Fetal, CTL-P1, CTL-P56, and co-upregulation of TBX5/TBX20/ERBB4/GRK5, which do not show any clusters explicit for ARP1-MIP28 cardiomyocytes on P30, P35, and P42. (D) Seurat-Monocle pipeline trajectory plot among CM1, CM2, and CM10, whereas CM1, CM2, and CM10 were defined in⁴⁰. (E) ScanPY pipeline UMAP plot visualizing 16 cardiomyocyte clusters (CMc1-CMc16) identified by ScanPY. (F) The proportion of cardiomyocytes from each cluster CMc1-CMc12 is displayed for each injury group and time point. (G) ScanPY pipeline, a summary of clusters that are: exclusive for ARp1-P28, Fetal, CTL-P1, CTL-P56, and co-upregulation of TBX5/TBX20/ERBB4/GRK5. (H) ScanPY pipeline trajectory plot among CM1, CM2, and CM10. For comparison, the figures for the AI-based method were available at⁴⁰.