Table 1.
Baseline characteristics of participants.
| Variables | Creatinine sex-stratified quartile(umol/L) | P-value | |||
|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | ||
| F (< 51.6) | F (51.6 ≤ 57.0) | F (57.0 ≤ 63.0) | F (63.0–97.0) | ||
| M (< 71.8) | M (71.8 ≤ 79.0) | M (79.0 ≤ 86.6) | M (86.6–106.0) | ||
| No of subjects | 49381 | 48853 | 50049 | 50456 | |
| Age,years | 41.5 ± 11.9 | 41.4 ± 12.1 | 42.0 ± 12.5 | 43.6 ± 13.8 | < 0.001 |
| Gender, n (%) | < 0.001 | ||||
| male | 27021 (54.7) | 27092 (55.5) | 27381 (54.7) | 27198 (53.9) | |
| female | 22360 (45.3) | 21761 (44.5) | 22668 (45.3) | 23258 (46.1) | |
| Creatinine | 57.5 ± 10.1 | 66.0 ± 10.6 | 72.2 ± 11.5 | 82.4 ± 13.1 | < 0.001 |
| male | 65.9 ± 4.7 | 75.4 ± 2.0 | 82.5 ± 2.2 | 93.4 ± 5.1 | < 0.001 |
| female | 47.3 ± 3.4 | 54.3 ± 1.5 | 59.7 ± 1.7 | 69.5 ± 6.0 | < 0.001 |
| BMI(kg/m2 ) | 23.1 ± 3.4 | 23.1 ± 3.3 | 23.2 ± 3.3 | 23.4 ± 3.3 | < 0.001 |
| SBP(mmHg) | 119.2 ± 16.3 | 118.4 ± 16.0 | 118.6 ± 16.2 | 119.6 ± 16.8 | < 0.001 |
| DBP(mmHg) | 74.2 ± 10.9 | 74.0 ± 10.7 | 74.0 ± 10.6 | 74.2 ± 10.9 | < 0.001 |
| FPG(mmol/L) | 4.9 ± 0.6 | 4.9 ± 0.6 | 4.9 ± 0.6 | 4.9 ± 0.6 | < 0.001 |
| Family history of diabetes | 1069 (2.2) | 1046 (2.1) | 1011 (2.0) | 1038 (2.1) | 0.334 |
| TC(mmol/L) | 4.7 ± 0.9 | 4.7 ± 0.9 | 4.7 ± 0.9 | 4.8 ± 0.9 | < 0.001 |
| TG(mmol/L) | 1.3 ± 1.2 | 1.3 ± 1.0 | 1.3 ± 1.0 | 1.4 ± 1.0 | < 0.001 |
| LDL-C(mmol/L) | 2.7 ± 0.7 | 2.8 ± 0.7 | 2.8 ± 0.7 | 2.8 ± 0.7 | < 0.001 |
| HDL-C(mmol/L) | 1.4 ± 0.3 | 1.4 ± 0.3 | 1.4 ± 0.3 | 1.4 ± 0.3 | 0.463 |
| BUN(mmol/L) | 4.4 ± 1.1 | 4.6 ± 1.1 | 4.7 ± 1.1 | 4.9 ± 1.2 | < 0.001 |
| ALT(IU/L) | 18.4 (13.0, 28.6) | 18.0 (12.9, 27.8) | 18.0 (12.9, 27.1) | 18.0 (13.0, 26.8) | < 0.001 |
| AST(IU/L) | 22.0 (18.5, 27.0) | 22.0 (18.5, 26.7) | 22.0 (18.5, 26.1) | 22.0 (18.9, 27.0) | < 0.001 |
| Drinking status (%) | < 0.001 | ||||
| Not recorded | 34771 (70.4) | 34186 (70) | 35583 (71.1) | 37141 (73.6) | |
| Current | 395 (0.8) | 313 (0.6) | 322 (0.6) | 237 (0.5) | |
| Former | 2040 (4.1) | 2161 (4.4) | 2204 (4.4) | 2137 (4.2) | |
| Non | 12175 (24.7) | 12193 (25.0) | 11940 (23.9) | 10941 (21.7) | |
| Smoking status (%) | < 0.001 | ||||
| Not recorded | 34771 (70.4) | 34186 (70) | 35583 (71.1) | 37141 (73.6) | |
| Current | 3142 (6.4) | 2932 (6.0) | 2746 (5.5) | 2398 (4.8) | |
| Former | 631 (1.3) | 650 (1.3) | 584 (1.2) | 579 (1.1) | |
| Non | 10837 (21.9) | 11085 (22.7) | 11136 (22.3) | 10338 (20.5) | |
F female, M male, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, TC total cholesterol, TG triglyceride, LDL-C low-density lipid cholesterol, HDL-C high-density lipoprotein cholesterol, BUN blood urea nitrogen, ALT alanine aminotransferase, AST aspartate aminotransferase.