Fig. 3. Facial pictures of 21 TRIP12 individuals.

From left to right and top to bottom; subject 1 at 16 years, subject 2 at 1 year 7 months, subject 4 at 23 years 6 months, subject 10 at 5 years 8 months, subject 11 at 2 years 11 months, subject 12 at 18 years 5 months, subject 13 at 8 years 5 months, subject 14 at 5 years 9 months, subject 17 at 7 years, subject 18 at 4 years 3 months, subject 21 at 9 years, subject 23 at 65 years, subject 24 at 10 years, subject 26 at 7 years, subject 27 at 22 years, subject 28 at 14 years 8 months, subject 31 at 4 years 2 months, subject 34 at 19 years, subject 35 at 13 years 6 months, subject 37 at 2 years 10 months, subject 38 at 4 years 9 months. Recurrent facial features include deep-set eyes with narrow palpebral fissures, fullness of the upper eyelids, a broad nasal tip and wide mouth with prominent Cupid’s bow and downturned corners. Ears are often large and low-set with prominent earlobes.