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. 2023 Feb 9;128(9):1611–1624. doi: 10.1038/s41416-023-02182-5

Fig. 3. Schematic overview of the molecular mechanisms of YAP/TAZ in BC progression and metastasis.

Fig. 3

In luminal BC, YAP/TAZ function as a tumour suppressor by disrupting a TEAD-ERα signalling axis; in HER2+ BC, YAP/TAZ activation is responsible for the transcriptional responses downstream of oncogenic signalling, including HER2, EGFR, etc; In TNBC, YAP/TAZ-TEAD complex cooperates with other transcription factors to synergically promote the oncogenic growth and metastasis, including AP1, ZEB1, KLF5, TBX3, etc. E2: 17β-estradiol, nRTK: non-receptor tyrosine kinase.