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. 2023 Apr 26;13:6851. doi: 10.1038/s41598-023-33977-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative cases of nLDs and cLDs in NR. (a) Schematic depiction of the collection of liver biopsy samples and their processing for both hematoxylin and eosin (H&E) staining for light microscopy and osmium staining for electron microscopy. (b) Schematic illustration of nLDs and cLDs in NR. (c–e) Biopsy sections from patients with (c) NASH showing nLDs in hepatocytes and those from patients with (d) DILI and (e) AIH showing both nLDs and cLDs in NR. AIH autoimmune hepatitis, cLDs in NR cytoplasmic lipid droplets in the nucleoplasmic reticulum, DILI drug-induced liver injury, NASH nonalcoholic steatohepatitis, nLDs nucleoplasmic lipid droplets.