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. 2023 Apr 26;13:6851. doi: 10.1038/s41598-023-33977-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Frequencies and correlations of nLDs and cLDs in NR. The study included 80 patients who underwent liver biopsy. A part of each liver biopsy specimen was dissected and fixed for electron microscopy observation. Six patients were excluded from analysis because the electron microscopy sample did not contain the corresponding background liver specimen. The frequencies of nLDs and cLDs in NR were determined by counting > 100 nuclei per specimen. (a) Frequency of nLDs in liver biopsy samples. (b) Frequency of cLDs in NR in liver biopsy samples. (c,d) Scatter plot showing a correlation between nLD and cLD in NR frequencies. Correlations were analyzed using the MINE method that captures a wide range of associations, functional and otherwise. AIH autoimmune hepatitis, cLDs in NR cytoplasmic lipid droplets in the nucleoplasmic reticulum, DILI drug-induced liver injury, MAS maximum asymmetry score, MIC maximal information coefficient, MINE maximal information-based nonparametric exploration, NASH nonalcoholic steatohepatitis, nLDs nucleoplasmic lipid droplets.