Table 7.
Prognostic factors analysis in TNBC
| Factors | N | Events (%) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|---|
| X2 | P-value | HR (95% CI) | P-value | |||
| All patients | 208 | 27(13.0) | ||||
| Age | 0.007 | 0.933 | ||||
| < 50 | 94 | 12(12.8) | ||||
| ≥ 50 | 114 | 15(13.2) | ||||
| Menstrual status | 0.004 | 0.949 | ||||
| Premenopausal | 99 | 13(13.1) | ||||
| Postmenopausal | 109 | 14(12.8) | ||||
| T stage | 5.632 | 0.017 | ||||
| T1, T2 | 148 | 14(9.5) | ref | |||
| T3, T4 | 60 | 13(21.7) | 2.097(0.628–5.890) | 0.066 | ||
| N stage | 4.345 | 0.037 | ||||
| N0 | 76 | 5(6.6) | ref | |||
| N + | 132 | 22(16.7) | 3.633(1.819–8.687) | 0.032 | ||
| Histological type | 0.054 | 0.816 | ||||
| IDC | 166 | 22(13.3) | ||||
| Others | 42 | 5(11.9) | ||||
| Histological grade | 5.253 | 0.022 | ||||
| I, II | 112 | 9(8.0) | ref | |||
| III | 96 | 18(18.8) | 1.202(0.816–2.651) | 0.059 | ||
| ki67 index | 1.824 | 0.177 | ||||
| < 14% | 17 | 4(23.5) | ||||
| ≥ 14% | 191 | 23(12.0) | ||||
| P53 status | 0.328 | 0.567 | ||||
| Negative | 82 | 12(14.6) | ||||
| Positive | 126 | 15(11.9) | ||||
| HER2 status | 3.807 | 0.051 | ||||
| 0 expression | 98 | 8(8.2) | ||||
| Low expression | 110 | 19(17.3) | ||||
| AR status | 14.083 | < 0.001 | ||||
| Negative | 136 | 9(6.6) | ref | |||
| Positive | 72 | 18(25.0) | 4.551(2.668–8.063) | 0.015 | ||
| EGFR status | 2.126 | 0.145 | ||||
| Negative | 141 | 15(10.6) | ||||
| Positive | 67 | 12(17.9) | ||||
| CK5/6 status | 0.049 | 0.825 | ||||
| Negative | 180 | 23(12.8) | ||||
| Positive | 28 | 4(14.3) | ||||
| Surgery | 0.002 | 0.964 | ||||
| Conservative | 47 | 6(12.8) | ||||
| Mastectomy | 161 | 21(13.0) | ||||
| Radiotherapy | 0.162 | 0.687 | ||||
| Yes | 153 | 19(12.4) | ||||
| No | 55 | 8(14.5) | ||||
| NAC effect | 3.897 | 0.048 | ||||
| pCR | 46 | 2(4.3) | ref | |||
| non-pCR | 162 | 25(15.4) | 3.825(1.864–5.991) | 0.029 | ||
IDC invasive ductal carcinoma, NAC neoadjuvant chemotherapy