Table 1.

Sepsis definitions used for analysis

	Antibiotic prescribed	Organ failure	Cultures	Other clinically relevant event	Sepsis source information available	Part of alternative definition 1	Part of alternative definition 2
Primary definition
Main sepsis definition	Yes	Yes	Positive or negative	No	Yes	–	–
Alternative definition
Definitive	Yes	Yes	Positive	No	Yes	Yes	Yes
Very probable, either:
(1) or	Yes	Yes	Positive	Yes	Yes	Yes	Yes
(2) or	Yes	Yes	Negative	No	Yes	Yes	Yes
(3)	Yes	Yes	Negative	Yes	Yes	Yes	Yes
Probable	No	Yes	NAa	No	No	Yes	No
Possible	No	Yes	NAa	Yes	No	No	No
SOFA increase definition based on Sepsis 3 (post hoc)
SOFA definition (“Sepsis 3”)	Yes	Yes	–		Variable	No	No

NA data not collected

^aData on cultures were only collected for patients that received antibiotics. SOFA definition was performed post hoc. Any patients that had an increase in SOFA score of at least 2 points over baseline (hospital admission) SOFA and that either were started antibiotics or received new antibiotics were considered as septic