Table 1.
List of top 10 up- and down-regulated genes of B. breve MCC1274 in the co-culture with IECs compared with the mono-culture.
| Rank | KO | Annotation | FC | q-value |
|---|---|---|---|---|
| Up-regulated gene | ||||
| 1 | K04072 | adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase | 6.26 | 3.0.E-48 |
| 2 | K01695 | trpA; tryptophan synthase alpha chain | 3.86 | 7.8.E-27 |
| 3 | K02784 | ptsH; phosphocarrier protein HPr | 6.29 | 3.0.E-25 |
| 4 | K01000 | mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase | 2.27 | 1.2.E-20 |
| 5 | K00053 | ilvC; ketol-acid reductoisomerase | 4.04 | 5.7.E-18 |
| 6 | K01925 | murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase | 2.38 | 1.2.E-17 |
| 7 | K03502 | umuC; DNA polymerase V | 6.61 | 4.6.E-17 |
| 8 | K03551 | ruvB; holliday junction DNA helicase RuvB | 3.24 | 3.5.E-16 |
| 9 | K01696 | trpB; tryptophan synthase beta chain | 3.13 | 2.2.E-15 |
| 10 | K01803 | TPI, tpiA; triosephosphate isomerase (TIM) | 4.48 | 5.9.E-15 |
| Down-regulated gene | ||||
| 1 | – | Hypothetical protein | 0.06 | 2.3.E-43 |
| 2 | – | Hypothetical protein | 0.12 | 4.2.E-17 |
| 3 | – | Hypothetical protein | 0.42 | 1.2.E-16 |
| 4 | – | Hypothetical protein | 0.45 | 6.8.E-16 |
| 5 | K03484 | scrR; LacI family transcriptional regulator, sucrose operon repressor | 0.37 | 3.4.E-15 |
| 6 | K01768 | E4.6.1.1; adenylate cyclase | 0.31 | 6.1.E-15 |
| 7 | – | Hypothetical protein | 0.11 | 2.8.E-14 |
| 8 | – | Hypothetical protein | 0.40 | 8.7.E-14 |
| 9 | – | Hypothetical protein | 0.10 | 2.4.E-13 |
| 10 | K05349 | bglX; beta-glucosidase | 0.09 | 1.6.E-12 |
FC, Fold change, KO, KEGG Orthology.