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. 2023 Apr 13;11:1124907. doi: 10.3389/fcell.2023.1124907

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Copyright © 2023 Davidson and Pickering.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proteasome modulation of long-term potentiation via regulation of CREB signaling. The proteasome regulates multiple factors impacting CREB function. This includes degradation of CREB repressor ATF4. cAMP-induced degradation of the R subunit of protein kinase alpha (PKA) produces free C subunit, which may enhance CREB function. Augmented BDNF expression also enhances CREB function. → is intended to denote causation. ┴ is intended to denote inhibition. ⇢ is intendend to denote causation through a mechanism that is not fully defined. Images Created with BioRender.com.