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. 2023 Apr 13;11:1124907. doi: 10.3389/fcell.2023.1124907

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Copyright © 2023 Davidson and Pickering.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proteasome modulation of dendritic spine growth. The proteasome plays key roles in dendritic sprine growth. It is thought that this occurs by Ca2+ influx through NMDA receptors, which localizes CaMKIIα to dendritic spines, resulting in the recruitment and activation of the proteasome in dendritic spines. Activation and localization of proteasome to the dendritic spines is thought to promote dendritic spine growth by increasing degradation of factors repressing spine growth. This process is counteracted by the plasma membrane 20S proteasome, which appears to degrade CaMKIIα. → is intended to denote causation. ┴ is intended to denote inhibition. Images Created with BioRender.com.