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. 2023 Apr 13;14:1133528. doi: 10.3389/fphys.2023.1133528

FIGURE 1.

FIGURE 1

Cortical spreading depression induced by potassium chloride and nitric oxide release induced by nitroglycerin can affect ROS/TRPA1/TRPVA/CGRP pathway, which forms positive feedback with CSD and NO, which leads to energy metabolism disorder and migraine.