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. 2023 Apr 13;14:1140856. doi: 10.3389/fphys.2023.1140856

FIGURE 1.

FIGURE 1

SSC5D transcript is highly elevated in failing hearts. (A) The Venn diagram shows the common genes between the secreted proteins and GSE165303 data. (B) The volcano map shows the significantly differentially expressed genes among 1,459 common genes. Red dots, significantly elevated genes; Blue dots, significantly downregulated genes; Grey dots, non-significantly altered genes. (C, D) The correlation between SSC5D (log2 [normalized counts]) and NPPA, NPPB (log2 [normalized counts]) in 51 NF and 50 DCM hearts RNA-seq data (GSE165303). (E) Normalized SSC5D expression values (log2 [normalized counts]) in 51 NF and 50 DCM human hearts RNA-seq data (GSE165303). (F) Normalized SSC5D expression (RPKM) in 8 NF and 8 ICM human hearts RNA-seq data (GSE46224). (G) Normalized SSC5D expression (RPKM) in 14 NF, 13 ICM and 37 DCM human hearts RNA-seq data (GSE116250). NF, non-failing; DCM, dilated cardiomyopathy; ICM, ischemic cardiomyopathy; p-value < 0.05 was considered statistically significant.