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. 2022 Dec 19;12(7):8289–8305. doi: 10.1002/cam4.5527

FIGURE 2.

FIGURE 2

Overexpression of circSWT1 promotes the viability, invasion, and migration of NSCLC cells. (A) The level of circSTW1 was lowest in A549 cells and highest in H1299 cells. [(B) and (C) The transfection efficiency of two stably transfected cell lines (A549‐circSWT1 and H1299‐shcircSWT1) was measured by qRT‐PCR. [(D) and (E)]. The viability of A549‐circSWT1 and H1299‐shcircSWT1 cells was assessed by CCK‐8 assays. (F) The viability of A549‐circSWT1 and H1299‐shcircSWT1 cells was assessed by colony formation assays. (G) The invasion of A549‐circSWT1 and H1299‐shcircSWT1 cells was evaluated using Matrigel Transwell assays. (H) The migration of A549‐circSWT1 and H1299‐shcircSWT1 cells was assessed by wound healing assays. (I) The number of lung metastases was higher in the A549‐circSWT1 group and lower in the H1299‐shcircSWT1 group than in the control group. The data are presented as the mean ± SD of three independent experiments. **p < 0.01, ***p < 0.001, ****p < 0.0001, ns: not significant.