TABLE 5.
Multivariate analysis of overall survival
| HR | 95% CI | p value | |
|---|---|---|---|
| Immune‐related liver injury | |||
| No (n = 233) | 1 | 0.720–3.053 | 0.285 |
| Yes (n = 30) | 1.483 | ||
| Immune‐related endocrine dysfunction | |||
| No (n = 234) | 1 | 0.466–2.111 | 0.982 |
| Yes (n = 29) | 0.992 | ||
| Proteinuria | |||
| No (n = 176) | 1 | 0.457–1.419 | 0.453 |
| Yes (n = 87) | 0.805 | ||
| Fatigue | |||
| No (n = 191) | 1 | 1.229–4.510 | 0.010 |
| Yes (n = 72) | 2.354 | ||
| Decreased appetite | |||
| No (n = 202) | 1 | 0.654–2.505 | 0.472 |
| Yes (n = 61) | 1.280 | ||
| Hypertension | |||
| No (n = 211) | 1 | 0.393–1.457 | 0.405 |
| Yes (n = 52) | 0.757 |
Abbreviations: CI, confidence interval; HR, hazard ratio.