TABLE 8.
Therapeutic response by non–immune‐related AEs
| Proteinuria | Fatigue | Decreased appetite | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Yes (n = 87) | No (n = 176) | p value | Yes (n = 72) | No (n = 191) | p value | Yes (n = 61) | No (n = 202) | p value | |
| CR | 5 (5.7%) | 8 (4.5%) | 0.044 | 1 (1.4%) | 12 (6.3%) | 0.218 | 0 (0.0%) | 13 (6.4%) | 0.042 |
| PR | 29 (33.3%) | 42 (23.9%) | 24 (33.3%) | 47 (24.6%) | 21 (34.4%) | 50 (24.8%) | |||
| SD | 45 (51.7%) | 87 (49.4%) | 33 (45.8%) | 99 (51.8%) | 26 (42.6%) | 106 (52.5%) | |||
| PD | 8 (9.2%) | 39 (22.2%) | 14 (19.4%) | 33 (17.3%) | 14 (23.0%) | 33 (16.3%) | |||
| ORR | 39.1% | 28.4% | 0.092 | 34.7% | 30.9% | 0.556 | 34.4% | 31.2% | 0.641 |
| DCR | 90.8% | 77.8% | 0.010 | 80.6% | 82.7% | 0.719 | 77.0% | 83.7% | 0.255 |
Abbreviations: AE, adverse event; CR, complete response; DCR; disease control rate; ORR, overall response rate; PD, progressive disease; PR, partial response; SD, stable disease.