Figure 2.

(A) Structures of ARVs investigated for inclusion in the core of targeted NPs, along with their classification based on molecular target: protease inhibitor (PI), integrase inhibitor (INI), nucleoside/nucleotide reverse transcriptase inhibitor (NRTI), and non-nucleoside reverse transcriptase inhibitor (NNRTI). (B) Heat maps for diameter, zeta potential, percent loading, and percent encapsulation efficiency of ARV-loaded NPs. (C) TEM images of T-EFV-NP, T-EVG-NP, and T-DRV-NP. (D) Release profiles of EFV, EVG, and DRV from T-NPs at pH 7.4 at 37 °C.