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In vivo distribution of intravenously injected T-ARV-NPs in the brain, liver, and blood of female Balb/c mice for (A) EFV and T-EFV-NP, (B) EVG and T-EVG-NP, and (C) DRV and T-DRV-NP. (D) Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in the blood plasma. The animals were dosed with 40 mg/kg with respect to the ARVs.
