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. Author manuscript; available in PMC: 2023 Apr 27.
Published in final edited form as: ACS Nano. 2021 Aug 6;15(10):15741–15753. doi: 10.1021/acsnano.0c09553

Figure 6.

Figure 6.

(A) Schematic of the experimental approach where microglia cells were fluorescently labeled with mito-GFP, followed by treatment with TAT peptide, methamphetamine, and a combination of T-DRV/EFV/ELV-NP. These microglia cells were then cocultured with astrocytes treated with a combination of T-(Asp)4-NP + T-CoQ10-NP. (B) Cellular levels of the inflammatory markers IL-1β, IL-6, and TNF-α in microglia after coculturing with NP-treated astrocytes. (C) ATP levels and (D) ROS levels in microglia after nourishing with astrocytes. AST: human astrocyte; AST*: neuroprotectant-loaded-NP-treated human astrocytes.