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. 2023 Apr 26;14:107. doi: 10.1186/s13287-023-03345-0

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The roles and mechanisms of various MSC-exos in promoting wound healing. MSC-exos, represented by ADSCs, BMSCs, hUC-MSCs, and other stem cell types, play a role in shaping the activity of fibroblasts, KCs, immune cells, and ECs. Specifically, the uploaded and shuttled proteins and ncRNAs within MSC-exos can trigger behavioral alterations in skin cells, such as proliferation, migration, invasion, differentiation, and polarization, consequently leading to angiogenesis, anti-inflammatory factor secretion, ECM reconstruction, anti-scarring effects, and tissue regeneration. Ultimately, these effects synergistically contribute to the accelerated or anti-scarring wound healing process. Figure 3 is partly generated using Servier Medical Art (https://smart.servier.com), provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license (https://creastivecommons.org/licenses/by/3.0/)