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. 2023 Apr 27;270(8):3862–3875. doi: 10.1007/s00415-023-11699-x

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Clinical deterioration event rate per 100 patient-years. ^a1-year period, events reported by investigators. The event rates were calculated using a generalized estimating equation Poisson regression repeated measures model with the number of events as the dependent variable, the logarithm of patient-years as the offset variable, and the study or phase indicator (pre-study, placebo, and ravulizumab RCP + OLE) as the factors, assuming a compound symmetry correlation structure. OLE, open-label extension; PY, patient-years; RCP, randomized controlled period