FIG 11.

Schematic model of PEAV entry into host cells. (Step 1) PEAV entry by clathrin-mediated endocytosis is dependent on dynamin. (Step 2) PEAV entry by caveola-mediated endocytosis requires cholesterol. (Step 3) PEAV activates macropinocytosis and depends on macropinocytosis endocytosis. (Step 4) After PEAV internalization, transport depends on Rab5 to regulate entry into early endosomes. (Step 5) Rab7 regulates early endosomal PEAV transport to the late endosomes or lysosomes. (Step 6) Rab9 regulates late endosomal entry into the Golgi apparatus. Finally, the virus core penetration is complete, and the genome is released.