Table 1.
Low-grade risk factors associated with the detection of high-grade precancerous or cancerous pancreatic lesions in score positive patients
| Without lesions (n=511) | PHP (n=10) | P (PHP vs. without lesions) | Resectable lesions (n=20) | P (resectable lesions vs. without lesions) | All lesions (n=33) | P (all lesions vs. without lesions) (univariate/multivariate logistic analysis) | |
|---|---|---|---|---|---|---|---|
| Mean age±SD, years | 67.9±12.2 | 70.4±7.1 | 0.526 | 70.6±8.8 | 0.336 | 71.9±9.3 | 0.070 |
| Male sex, n (%) | 312 (61.1) | 8 (80.0) | 0.239 | 16 (80.0) | 0.098 | 21 (63.6) | 0.087 |
| LGRF n (%) | |||||||
| Sporadic family history | 73 (14.3) | 2 (20.0) | 0.613 | 4 (20.0) | 0.479 | 4 (12.1) | 0.730 |
| DM | 185 (36.2) | 3 (30.0) | 0.687 | 6 (30.0) | 0.572 | 11 (33.3) | 0.739 |
| DM worsening | 54 (10.6) | 0 | 0.997 | 1 (5.0) | 0.435 | 3 (9.1) | 0.789 |
| Heavy drinking | 199 (38.9) | 7 (70.0) | 0.062 | 11 (55.0) | 0.156 | 14 (42.4) | 0.692 |
| Smoking history | 153 (29.9) | 4 (40.0) | 0.496 | 10 (50.0) | 0.063 | 13 (39.4) | 0.256 |
| Obesity | 143 (30.0) | 3 (30.0) | 0.888 | 4 (20.0) | 0.437 | 8 (24.2) | 0.642 |
| Stomach symptoms or back pain | 140 (27.4) | 3 (30.0) | 0.855 | 7 (35.0) | 0.458 | 17 (51.5) | 0.004*/0.060 |
| Weight loss | 101 (19.8) | 0 | 0.997 | 7 (35.0) | 0.105 | 18 (54.5) | <0.001*/0.001* |
| Pancreatic enzyme | 63 (12.3) | 3 (30.0) | 0.113 | 6 (30.0) | 0.028* | 8 (24.2) | 0.055 |
| Score valuation | |||||||
| Mean LGRS±SD, point | 2.2±1.5 | 2.5±1.0 | 0.459 | 2.8±1.1 | 0.056 | 2.9±1.0 | 0.004*/0.505 |
| LGRS positive, n (%) | 230 (45.0) | 6 (60.0) | 0.353 | 13 (65.0) | 0.086 | 24 (72.7) | 0.003*/0.222 |
*P<0.05 compared to patients without pancreatic high-grade precancerous lesion and PC. DM: Diabetes mellitus; LGRF: Low-grade risk factors; LGRS: Low-grade risk score; PC: Pancreatic cancer; PHP: Pancreatic high-grade precancerous lesion; SD: Standard deviation