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. 2023 Mar 24;12(4):794. doi: 10.3390/antiox12040794

Figure 3.

Figure 3

Gene expression of proinflammatory, profibrotic, and interferon genes in HMGB1 or TGF-β stimulated dermal fibroblasts. (A) Dermal fibroblasts were stimulated with HMGB-1 and gene expression of IL-6, Col-1, CTGF, A-SMA, IFI44L, Mx1, IP-10 and Ly6e were investigated. (B) a RAGE inhibitor (FPS-ZM1) was used before HMGB-1 stimulation and IL-6, IFI44L, Mx1 and IP-10 gene expression was analyzed. (C) Dermal fibroblasts were stimulated with TGF-β and gene expression of IL-6, Col-1, CTGF, A-SMA, IFI44L, Mx1, IP-10 and Ly6e were investigated. (D) a RAGE inhibitor (FPS-ZM1) was used before TGF-β stimulation and IL-6, IFI44L, Mx1 and IP-10 gene expression was analyzed. Statistical significance: * p < 0.05, ** p < 0.01. High mobility group box 1 (HMGB1), transforming growth factor β (TGF-β), Interleukin-6 (IL-6), collagen-1α (Col-1α), connective tissue growth factor (CTGF), α-smooth muscle actin (α-SMA), IFN α-induced 44L (IFI44L), Myxovirus resistance protein 1 (Mx1), Lymphocyte antigen 6 complex, locus E (LY6E), and interferon-γ-inducible protein-10 (IP-10).