Table 1.

Clinical characteristics of subjects who underwent the cooling experiment.

	Healthy Controls (HC) n = 10	Primary Raynaud Phenomenon (PRP) n = 10	Systemic Sclerosis (SSc) n = 10
Age (years), mean ±SD	29.9 ± 2.7	47.8 ± 16.2	56.2 ± 11.5
Female gender, n	7	8	5
Disease duration (years), median (IQR)	N/A	8.0 (4.0–17.0)	4.5 (3.0–6.3)
Abnormal NCM pattern, n	0	0	10
Positive autoantibodies, n	0	0	8
Organ involvement, n
Pulmonary	0	0	0
Oesophageal	0	0	3
Comorbidities
Diabetes, n	0	1	0
Hypertension, n	0	1	2
Hypercholesteremia, n	0	0	1
Creatinine, median (IQR)	72.1 [66.5–77.6]	72.0 [63.5–72.0]	76.2 [63.5–88.6]
eGFR, median (IQR)	94.5 [90.6–114.8]	79.3 [68.3–97.4]	86.6 [74.1–98.5]
History of Digital ulcers, n	0	0	6
Relevant medication, n
Immunosuppressants
Plaquenil	0	0	1
Mycophenolate mofetil	0	0	1
Calcium channel blockers
Nifedipine	0	1	2
Vasodilators
Iloprost	0	0	2
Bosentan	0	0	3
Other antihypertensives	0	1	3
Lipid-lowering drugs	0	0	1
Glucose-lowering drugs	0	1	0
Anticoagulants	0	1	2

N/A: Not Available; NCM: Nailfold capillary microscopy; eGFR: estimated glomerular filtration rate.