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. 2023 Mar 25;12(4):804. doi: 10.3390/antiox12040804

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Non-coding RNAs characterized in neurological disorders associated with mitochondrial-cellular parameters in response to Mn dose. (A) Environmental stressor (Mn) subnetwork includes positively associated miRNA involved in regulation of autophagy-related protein PINK1, MIR27a. (B) Oxidative phosphorylation (mtOCR) subnetwork includes Huntington’s disease-related miRNA, MIR9-1; anti-inflammatory-related miRNA, MIRLET7A1; and cell migration-related lncRNA, DEPDC1-AS1. (C) Total cellular thiols subnetwork includes positively associated Alzheimer’s-related lncRNA, EPHA1-AS1. (D) Mitochondrial oxidative stress (mtOx) subnetwork includes stroke-related miRNA, MIR149, Alzheimer’s-related lncRNA, KIAA0125 and neurobehavioral-associated lncRNA, PAX8-AS1. The intensity for functional measures on the x-axis is indicative of Mn exposure low–med–high from left to right. Details on all associated non-coding miRNAs and lncRNAs are provided Tables S1, S3, S5 and S6. |r| > 0.8, p < 0.05.